NOD. scid is a loss-of-function mutation of the Prkdc gene that prevents the development of T and B cells. It should be noted that this chapter will provide an introductory overview of care of NOD mice and will not. Consequently, macrophages and dendritic cells are defective. These include those which are globally immunodeficient that include NOD.scid mice and NOD.RAG2/ mice as well as alpha-beta TCR-deficient, B cell-deficient, and more specialized models where individual immune subsets can be depleted. NOD.Cg- Kit W-41JTyr +Prkdc scidIl2rg tm1Wjl/ThomJ ( 026622) The NOD genetic background contains alleles that reduce the function of the innate branch of the immune system. Using the newly combined immunodeficient NOD-scid IL2rgamma(null) mice and Rag2(null) IL2rgamma(null) humanized mice, it has became possible to expand applications because various hematopoietic cells can be differentiated by human hematopoietic stem cell transplantation, and the human immune system can be reconstituted to some degree. Severe Combined Immunodeficiency (SCID) is an inherited group of rare, life-threatening disorders due to the defect in T cell development and function. NOD.Cg- Prkdc scidIl2rg tm1Wjl Tg(IL15)1Sz/SzJ ( 030890) NOD/SCID mice are not as commonly used to generate humanized mice because they require a higher dose of HSCs for efficient engraftment, compared with more deficient mouse strains like NOD/SCID rg null mice and they developed thymic lymphomas shortening their lifespan. NOD.Cg- Prkdc scidH2-Ab1 em1MvwH2-K1 tm1BpeH2-D1 tm1BpeIl2rg tm1Wjl/SzJ ( 025216) NOD.Cg- B2m tm1UncPrkdc scidIl2rg tm1Wjl/SzJ ( 010636) NOD.Cg- Prkdc scidH2-K1 tm1BpeH2-D1 tm1BpeIl2rg tm1Wjl/SzJ ( 023848) NOD.Cg-Tg(HLA-DRA*0101,HLA-DRB1*0101) 1Dmz Prkdc scid Il2rg tm1Wjl/GckRolyJ ( 012479) NOD.Cg- Prkdc scidIl2rg tm1WjlH2-Ab1 tm1Doi Tg(HLA-DRB1)31Dmz/SzJ ( 017637) The NOD/SCID/IL2r null (NSG) mouse is one of the most widely used immunocompromised mouse strains it allows engraftment with human hematopoietic stem cells and/or human tissues and the subsequent development of a functional human immune system. NOD SCID bezeichnet ein Mausmodell, das in der biologischen Forschung insbesondere in der Krebs- und Diabetesforschung breite Anwendung findet. NOD.Cg- Prkdc scid Il2rg tm1Wjl Tg(CMV-I元,CSF2,KITLG)1Eav/MloySzJ ( 013062) Nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mouse as a model system to study the engraftment and mobilization of human peripheral blood stem cells. NOD.Cg- Prkdc scidIl2rg tm1Wjl/SzJ ( 005557)
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